Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Individualized Monitoring of Nuclear Factor of Activated T Cells-Regulated Gene Expression in FK506-Treated Kidney Transplant Recipients

12 May 2010

Abstract excerpt

BACKGROUND: The suggested key mechanism of both cyclosporine A (CsA) and FK506 is the inhibition of calcineurin phosphatase activity, preventing nuclear factor of activated T cells (NFAT)-translocation into the nucleus of T cells, with a subsequent transcriptional block of crucial cytokine genes. However, the two drugs exert different clinical activities as exemplified by the ability of FK506 to treat acute...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Oral and gingival health research
Share to Renal Transplantation Outcomes and Treatments
Share to Signaling Pathways in Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20463649
DOI: 10.1097/tp.0b013e3181dc13b6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Individualized Monitoring of Nuclear Factor of Activated T Cells-Regulated Gene Expression in FK506-Treated Kidney Transplant RecipientsPMID 20463649Read ↗

Analysis of NFAT-regulated gene expression in vivo: a novel perspective for optimal individualized doses of calcineurin inhibitorsSemantic proximity Read ↗

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and FunctionSemantic proximity Read ↗

Clinical development of gene edited tacrolimus-resistant Treg (FKBP12 <sup>KO</sup> -Treg) to enable simultaneous immunosuppression and support of immune regulationSemantic proximity Read ↗

In vivo mechanisms for the inhibition of T lymphocyte activation by long-term therapy with tacrolimus (FK-506): experience in patients with Behçet's disease.Semantic proximity Read ↗

FKBP1A rs6041749 polymorphism is associated with allograft function in renal transplant patients.Semantic proximity Read ↗

Pharmacodynamic immune monitoring of NFAT‐regulated genes predicts skin cancer in elderly long‐term renal transplant recipientsSemantic proximity Read ↗

NFATC1 genotypes affect acute rejection and long-term graft function in cyclosporine-treated renal transplant recipients.Semantic proximity Read ↗

Regulation of calcineurin phosphatase activity and interaction with the FK-506.FK-506 binding protein complex.Semantic proximity Read ↗

Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from alpha-factor arrest in yeast.Semantic proximity Read ↗

Declining intracellular T-lymphocyte concentration of cyclosporine a precedes acute rejection in kidney transplant recipients.Semantic proximity Read ↗

A role of calcineurin in coreceptor regulation during differentiation of Cd4+Cd8+ T cells.Semantic proximity Read ↗

Immunomodulatory effect of pentoxifylline during human allograft rejection: involvement of tumor necrosis factor-alpha and adhesion molecules.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.