Pharmacodynamic immune monitoring of NFAT‐regulated genes predicts skin cancer in elderly long‐term renal transplant recipients

Abstract excerpt

INTRODUCTION: Among elderly allograft recipients non-melanoma skin cancer (NMSC) is the most common malignancy. We have previously shown that malignancies are associated with a higher intensity of ciclosporin A (CsA)-induced immunosuppression. METHOD: Fifty-five long-term elderly renal transplant patients with a stable transplant function had regular skin examinations. The expression of the nuclear factor of...

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