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Article

Analysis of NFAT-regulated gene expression in vivo: a novel perspective for optimal individualized doses of calcineurin inhibitors

1 Jul 2004

Abstract excerpt

BACKGROUND: With the introduction of cyclosporine A (CsA) long-term allograft function has been significantly improved. Problems regarding limited therapeutic margins and CsA toxicity remain unsolved. Up to now there are no reliable, practical markers to measure the biological activity of CsA in vivo. METHODS: Expression of nuclear factor of activated T lymphocytes (NFAT)-regulated genes in...

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PMID: 15240851
DOI: 10.1093/ndt/gfh1043

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