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Article

A role of calcineurin in coreceptor regulation during differentiation of Cd4+Cd8+ T cells.

Biochemical and biophysical research communications - 18 Jun 1998

Kuwata T, Asada A, Ohoka Y, Mukai M, Miyaike M, Iwata M

Abstract excerpt

The immunosuppressant FK506 inhibits thymocyte positive selection. Calcineurin, a FK506-sensitive Ca2+/calmodulin-dependent protein phosphatase, is presumed to be involved in this event without direct evidence. We have previously shown that moderate stimulation of CD4(+)CD8(+) thymocytes with a combination of the calcium ionophore ionomycin and phorbol myristate acetate mimics positive selection events including...

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Identifiers

PMID: 9642110
DOI: 10.1006/bbrc.1998.8767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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