Article
Declining intracellular T-lymphocyte concentration of cyclosporine a precedes acute rejection in kidney transplant recipients.
Transplantation - 27 Jan 2008
Falck Pål, Asberg Anders, Guldseth Heidi, Bremer Sara, Akhlaghi Fatemeh, Reubsaet Jan L E, Pfeffer Per, Hartmann Anders, Midtvedt Karsten
Abstract excerpt
BACKGROUND: We investigated cyclosporine A (CsA) concentrations at the site of action, inside T-lymphocytes, to evaluate its applicability as a new supplementary therapeutic drug monitoring method after renal transplantation. METHOD: In this prospective single-center study, 20 kidney transplant recipients, mean age 54 (range 21-74) years, on CsA-based immunosuppression were included within 2 weeks posttransplant...
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