Article

Clinical development of gene edited tacrolimus-resistant Treg (FKBP12 <sup>KO</sup> -Treg) to enable simultaneous immunosuppression and support of immune regulation

2025-12-13

Abstract excerpt

<h4>Background: </h4> Unwanted immune responses play a central role in the pathogenesis of solid organ allograft rejection. These are managed by life-long immunosuppression with considerable burden for the patient and society. Adoptive therapy with regulatory T-cells (Treg) is a promising approach to restore sustainable immune balance and avoid long-term adverse effects of immunosuppression. While Treg effectively...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ff854135-2b02-59b4-a5de-43fb8679bae2
DOI: 10.64898/2025.12.10.693159

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Clinical development of gene edited tacrolimus-resistant Treg (FKBP12 <sup>KO</sup> -Treg) to enable simultaneous immunosuppression and support of immune regulationDOI 10.64898/2025.12.10.693159Read

CRISPR-Cas9-Edited Tacrolimus-Resistant Antiviral T Cells for Advanced Adoptive Immunotherapy in Transplant RecipientsSemantic proximity Read

Clinical adoptive regulatory T Cell therapy: State of the art, challenges, and prospectiveSemantic proximity Read

Past, Present, and Future of Regulatory T Cell Therapy in Transplantation and AutoimmunitySemantic proximity Read

Effector memory-type regulatory T cells display phenotypic and functional instability.Semantic proximity Read

Regulatory T cells in solid organ transplantationSemantic proximity Read

Engineering CAR T Cells for Hepatocellular Carcinoma Recurrence after Liver TransplantationSemantic proximity Read

Overcoming barriers to widespread use of CAR-Treg therapy in organ transplant recipients.Semantic proximity Read

Optimized CRISPR-mediated gene knock-in reveals FOXP3-independent control of human Treg identitySemantic proximity Read

Super-Treg: Toward a New Era of Adoptive Treg Therapy Enabled by Genetic ModificationsSemantic proximity Read

Unlocking the potential of Tregs: innovations in CAR technologySemantic proximity Read

Gene editing of CD3 epsilon to redirect regulatory T cells for adoptive T cell transferSemantic proximity Read

Future prospects for CD8+ regulatory T cells in immune toleranceSemantic proximity Read