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TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1 Apr 1997

Abstract excerpt

As targets for the immunosuppressive drugs cyclosporin A and FK506, transcription factors of the NFAT (nuclear factor of activated T cells) family have been the focus of much attention. NFAT proteins, which are expressed in most immune-system cells, play a pivotal role in the transcription of cytokine genes and other genes critical for the immune response. The activity of NFAT proteins is tightly regulated by the...

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PMID: 9143705
DOI: 10.1146/annurev.immunol.15.1.707

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