Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from alpha-factor arrest in yeast.

doi:10.1038/360682a0

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Article

Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from alpha-factor arrest in yeast.

Nature - 17 Dec 1992

Foor F, Parent S A, Morin N, Dahl A M, Ramadan N, Chrebet G, Bostian K A, Nielsen J B

Abstract excerpt

The structurally unrelated immunosuppressants FK506 and cyclosporin A (CsA) act similarly, inhibiting a Ca(2+)-dependent signal required for interleukin-2 transcription and T-cell activation. Each drug binds to its cytosolic receptor, FKBP-12 and cyclophilin, respectively, and the drug-receptor complexes inhibit the Ca2+/calmodulin-dependent protein phosphatase, calcineurin. In yeast, calcineurin has been...

Topics

Alleles
Calcineurin
Calmodulin-Binding Proteins
Carrier Proteins
Cyclosporine
DNA, Fungal
Genes, Fungal
Haploidy
Macromolecular Substances
Mating Factor
Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pheromones

Phosphoprotein Phosphatases

Polymerase Chain Reaction

Restriction Mapping

Saccharomyces cerevisiae

Tacrolimus

Tacrolimus Binding Proteins

Source

Open in PubMed

Identifiers

PMID: 1281518
DOI: 10.1038/360682a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1281518-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from alpha-factor arrest in yeast.PMID 1281518Read ↗

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