Article
MDM2 gene amplification in colorectal cancer is associated with disease progression at the primary site, but inversely correlated with distant metastasis.
Genes, chromosomes & cancer - 1 Jul 2010
Sugano Nobuhiro, Suda Tetsuji, Godai Ten-I, Tsuchida Kazuhito, Shiozawa Manabu, Sekiguchi Hironobu, Yoshihara Mitsuyo, Matsukuma Shoichi, Sakuma Yuji, Tsuchiya Eiju, Kameda Yoichi, Akaike Makoto, Miyagi Yohei
Abstract excerpt
MDM2 is a crucial negative regulator of the TP53 tumor suppressor and almost 10% of human tumors exhibit MDM2 amplification. Although TP53 pathway perturbation has been extensively examined in colorectal cancer (CRC), only one previous report has evaluated MDM2 amplification in relation to clinicopathological factors. In that report, MDM2 amplification was shown to be associated with disease progression from...
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