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Article

The role of MDM2 amplification and overexpression in therapeutic resistance of malignant tumors

22 Aug 2019

Abstract excerpt

The MDM2 protein encoded by the mouse double minute 2 ( MDM2 ) gene is the primary negative regulatory factor of the p53 protein. MDM2 can ligate the p53 protein via its E3 ubiquitin ligase, and the ubiquitinated p53 can be transferred to the cytoplasm and degraded by proteasomes. Therefore, MDM2 can maintain the stability of p53 signaling pathway. MDM2 amplification has been detected in many human malignancies,...

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PMID: 31440117
DOI: 10.1186/s12935-019-0937-4

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