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Article

VEGFA gene locus (6p12) amplification identifies a small but highly aggressive subgroup of colorectal cancer [corrected] patients.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Oct 2011

Vlajnic Tatjana, Andreozzi Maria Carla, Schneider Sandra, Tornillo Luigi, Karamitopoulou Eva, Lugli Alessandro, Ruiz Christian, Zlobec Inti, Terracciano Luigi

Abstract excerpt

The aim of this study was to determine: (1) the frequency of VEGFA gene locus (6p12) amplification in colorectal cancers, (2) the effect of gene amplification on clinical outcome using two independent colorectal cancer patient cohorts and (3) the relationship between amplification and KRAS or BRAF gene mutation as well as with other RAS/MAPK signalling proteins. Single-punch (n=1280; cohort 1) and multiple-punch...

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Source

Identifiers

PMID: 21743435
DOI: 10.1038/modpathol.2011.96

Genes

VEGFA
BRAF
KRAS
MAPK1
MAPK3
PEBP1
PLAU
HMMR
PLAUR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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