Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Concurrent amplification of cyclin E and CDK2 genes in colorectal carcinomas

4 Jul 1995

Abstract excerpt

The genetic changes of cyclin A, DI, E and CDK2 were examined in human colorectal carcinomas by Southern-blot analysis. Gene amplification of cyclin E was detected in 5 of 53 (9.4%) primary colorectal carcinoma tissues. Interestingly, in 3 of 5 tumors showing cyclin E gene amplification, the CDK2 gene was amplified simultaneously with rearrangements. No obvious correlation was detected between gene amplification...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Pancreatic and Hepatic Oncology Research
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7601562
DOI: 10.1002/ijc.2910620107

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Concurrent amplification of cyclin E and CDK2 genes in colorectal carcinomasPMID 7601562Read ↗

Expression and gene amplification of primary (A, B1, D1, D3, and E) and secondary (C and H) cyclins in colon adenocarcinomas and correlation with patient outcomeSemantic proximity Read ↗

Frequent Amplification of the Cyclin E Gene in Human Gastric CarcinomasSemantic proximity Read ↗

Expression of D-type cyclins in colon cancer and in cell lines from colon carcinomasSemantic proximity Read ↗

Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer.Semantic proximity Read ↗

MDM2 gene amplification in colorectal cancer is associated with disease progression at the primary site, but inversely correlated with distant metastasis.Semantic proximity Read ↗

Redundant cyclin overexpression and gene amplification in breast cancer cells.Semantic proximity Read ↗

Cyclin gene amplification and overexpression in breast and ovarian cancers: Evidence for the selection ofcyclin D1 in breast andcyclin E in ovarian tumorsSemantic proximity Read ↗

NF-Y–Dependent Cyclin B2 Expression in Colorectal AdenocarcinomaSemantic proximity Read ↗

Expressions of Cell Cycle Regulators in Human Colorectal Cancer Cell LinesSemantic proximity Read ↗

Cyclin D1 overexpression in colorectal carcinoma in vivo is dependent on beta-catenin protein dysregulation, but not k-ras mutation.Semantic proximity Read ↗

The PRAD‐1/cyclin D1 oncogene product accumulates aberrantly in a subset of colorectal carcinomasSemantic proximity Read ↗

Amplification and Overexpression of Cyclin D1 in Human Hepatocellular CarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.