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Article

c-MYC Copy-Number Gain Is an Independent Prognostic Factor in Patients with Colorectal Cancer

1 Oct 2015

Abstract excerpt

BACKGROUND: The aim of this study was to determine the incidence and clinicopathological significance of c-MYC gene copy-number (GCN) gain in patients with primary colorectal cancer (CRC). METHODS: The c-MYC GCN was investigated in 367 consecutive CRC patients (cohort 1) by using dual-color silver in situ hybridization. Additionally, to evaluate regional heterogeneity, we examined CRC tissue from 3 sites...

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PMID: 26426996
DOI: 10.1371/journal.pone.0139727

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