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Article

MDM2 gene amplification in esophageal carcinoma.

Oncology reports - 1 Apr 2016

Michalk Maike, Meinrath Jeannine, Künstlinger Helen, Koitzsch Ulrike, Drebber Uta, Merkelbach-Bruse Sabine, Bollschweiler Elfriede, Kloth Michael, Hartmann Wolfgang, Hölscher Arnulf, Quaas Alexander, Grimminger Peter P, Odenthal Margarete

Abstract excerpt

Esophageal cancer (EC) is one of the most common malignancies diagnosed in the Western world with an increasing incidence noted for esophageal adenocarcinoma (EAC). Despite improvements in staging, surgical procedures and postoperative treatments, the overall survival of patients with EC remains low. Murine double minute‑2 (MDM2) acts as an oncogene by inducing the degradation of the tumor‑suppressor protein...

Read the complete abstract on PubMed

Topics

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Share to Adenocarcinoma
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Esophageal Neoplasms

Share to Gene Amplification

Share to In Situ Hybridization, Fluorescence

Share to Proto-Oncogene Proteins c-mdm2

Share to Tumor Suppressor Protein p53

Share to Up-Regulation

Source

Identifiers

PMID: 26796597
DOI: 10.3892/or.2016.4578

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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