Article
Rare MDM4 gene amplification in colorectal cancer: The principle of a mutually exclusive relationship between MDM alteration and TP53 inactivation is not applicable.
Oncology reports - 1 Jul 2011
Suda Tetsuji, Yoshihara Mitsuyo, Nakamura Yoshiyasu, Sekiguchi Hironobu, Godai Ten-I, Sugano Nobuhiro, Tsuchida Kazuhito, Shiozawa Manabu, Sakuma Yuji, Tsuchiya Eiju, Kameda Yoichi, Akaike Makoto, Matsukuma Shoichi, Miyagi Yohei
Abstract excerpt
MDM4, a homolog of MDM2, is considered a key negative regulator of p53. Gene amplification of MDM4 has been identified in a variety of tumors. MDM2 or MDM4 gene amplification is only associated with the wild-type TP53 gene in retinoblastomas, thus the amplification of the two genes is mutually exclusive. Previously, we demonstrated that MDM2 amplification and TP53 alteration were not mutually exclusive in...
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