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Article

MDM2 amplification is rare in gastric cancer.

Virchows Archiv : an international journal of pathology - 1 Dec 2023

Abdullazade Samir, Behrens Hans-Michael, Krüger Sandra, Haag Jochen, Röcken Christoph

Abstract excerpt

The MDM2 proto-oncogene (MDM2) is a primary negative regulator of p53. The latter is frequently mutated in gastric cancer (GC). In the present study, we aimed to validate gene amplification, protein expression, and the putative tumor biological function of MDM2 in a well-characterized Western GC cohort. MDM2 amplification and protein expression were studied in a cohort of 327 GCs by fluorescence in situ...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37821635
DOI: 10.1007/s00428-023-03674-8
PMCID: PMC10700221

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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