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Article

MDM2 gene amplification is correlated to tumor progression but not to the presence of SNP309 or TP53 mutational status in primary colorectal cancers.

Molecular cancer research : MCR - 1 Feb 2008

Forslund Ann, Zeng Zhaoshi, Qin Li-Xuan, Rosenberg Shoshana, Ndubuisi MacKevin, Pincas Hanna, Gerald William, Notterman Daniel A, Barany Francis, Paty Philip B

Abstract excerpt

Mdm2 is the main regulator of p53 and is amplified in approximately 7% of all human cancers. MDM2 gene amplification as well as expression has been correlated to an increased tumorigenic potential. We have analyzed the prevalence of MDM2 gene amplifications and SNP309 in 284 colorectal tumors usi...

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Share to Colorectal Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

Share to In Situ Hybridization, Fluorescence

Share to Proto-Oncogene Proteins c-mdm2

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Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 18314481
DOI: 10.1158/1541-7786.MCR-07-0239

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18314481-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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