Article
RNA editing modulates the binding of drugs and highly unsaturated fatty acids to the open pore of Kv potassium channels.
The EMBO journal - 7 Jul 2010
Decher Niels, Streit Anne K, Rapedius Markus, Netter Michael F, Marzian Stefanie, Ehling Petra, Schlichthörl Günter, Craan Tobias, Renigunta Vijay, Köhler Annemarie, Dodel Richard C, Navarro-Polanco Ricardo A, Preisig-Müller Regina, Klebe Gerhard, Budde Thomas, Baukrowitz Thomas, Daut Jürgen
Abstract excerpt
The time course of inactivation of voltage-activated potassium (Kv) channels is an important determinant of the firing rate of neurons. In many Kv channels highly unsaturated lipids as arachidonic acid, docosahexaenoic acid and anandamide can induce fast inactivation. We found that these lipids interact with hydrophobic residues lining the inner cavity of the pore. We analysed the effects of these lipids on Kv1.1...
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