Article
RNA editing in eag potassium channels: biophysical consequences of editing a conserved S6 residue.
Channels (Austin, Tex.) - 1 Jan 2000
Ryan Mary Y, Maloney Rachel, Fineberg Jeffrey D, Reenan Robert A, Horn Richard
Abstract excerpt
RNA editing at four sites in eag, a Drosophila voltage-gated potassium channel, results in the substitution of amino acids into the final protein product that are not encoded by the genome. These sites and the editing alterations introduced are K467R (Site 1, top of the S6 segment), Y548C, N567D and K699R (sites 2-4, within the cytoplasmic C-terminal domain). We mutated these residues individually and expressed...
Topics
- Amino Acid Sequence
- Amino Acids
- Animals
- Biophysical Phenomena
- Cations
- Conserved Sequence
- Drosophila Proteins
- Drosophila melanogaster
- Ether-A-Go-Go Potassium Channels
- Extracellular Space
- Ion Channel Gating