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Article

The role of the cytoplasmic pore in inward rectification of Kir2.1 channels.

The Journal of general physiology - 1 Aug 2007

Kurata Harley T, Cheng Wayland W, Arrabit Christine, Slesinger Paul A, Nichols Colin G

Abstract excerpt

Steeply voltage-dependent block by intracellular polyamines underlies the strong inward rectification properties of Kir2.1 and other Kir channels. Mutagenesis studies have identified several negatively charged pore-lining residues (D172, E224, and E299, in Kir2.1) in the inner cavity and cytoplasmic domain as determinants of the properties of spermine block. Recent crystallographic determination of the structure...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17635958
DOI: 10.1085/jgp.200709742
PMCID: PMC2151631

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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