Article

Polyunsaturated fatty acid analogues differentially affect cardiac Na <sub>v</sub> , Ca <sub>v</sub> , and K <sub>v</sub> channels through unique mechanisms

2019-09-19

Abstract excerpt

The cardiac ventricular action potential depends on several voltage-gated ion channels, including Na v , Ca v , and K v channels. Mutations in these channels can cause Long QT Syndrome (LQTS) which increases the risk for ventricular fibrillation and sudden cardiac death. Polyunsaturated fatty acids (PUFAs) have emerged as potential therapeutics for LQTS because they are modulators of voltage-gated ion channels....

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Literature Corpus work: b254d3e4-7654-5aa0-a6b6-4800ded736b2
DOI: 10.1101/772640

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