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Article

Kv11.1 (ERG1) K+ channels localize in cholesterol and sphingolipid enriched membranes and are modulated by membrane cholesterol.

Channels (Austin, Tex.) - 1 Jan 2000

Balijepalli Ravi C, Delisle Brian P, Balijepalli Sadguna Y, Foell Jason D, Slind Jessica K, Kamp Timothy J, January Craig T

Abstract excerpt

The localization of ion channels to specific membrane microdomains can impact the functional properties of channels and their role in cellular physiology. We determined the membrane localization of human Kv11.1 (hERG1) alpha-subunit protein, which underlies the rapidly activating, delayed rectifier K(+) current (I(Kr)) in the heart. Immunocytochemistry and membrane fractionation using discontinuous sucrose...

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Source

Identifiers

PMID: 18708743
DOI: 10.4161/chan.4946

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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