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Mechanistic insights into robust cardiac I <sub>Ks</sub> potassium channel activation by aromatic polyunsaturated fatty acid analogues

2023-01-16

Abstract excerpt

Voltage-gated potassium (K V ) channels are important regulators of cellular excitability and control action potential repolarization in the heart and brain. K V channel mutations lead to disordered cellular excitability. Loss-of-function mutations, for example, result in membrane hyperexcitability, a characteristic of epilepsy and cardiac arrhythmias. Interventions intended to restore K V channel function have...

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Identifiers and source

Literature Corpus work
8e445f95-a2ee-5d69-893d-917cd476ec67
DOI
10.1101/2023.01.12.523777
Open publication

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Mechanistic insights into robust cardiac I <sub>Ks</sub> potassium channel activation by aromatic polyunsaturated fatty acid analoguesDOI 10.1101/2023.01.12.523777
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