Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondria take center stage in aging and neurodegeneration.

Annals of neurology - 1 Oct 2005

Beal M Flint

Abstract excerpt

A critical role of mitochondrial dysfunction and oxidative damage has been hypothesized in both aging and neurodegenerative diseases. Much of the evidence has been correlative, but recent evidence has shown that the accumulation of mitochondrial DNA mutations accelerates normal aging, leads to oxidative damage to nuclear DNA, and impairs gene transcription. Furthermore, overexpression of the antioxidant enzyme...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mutation
Share to Neurodegenerative Diseases
Share to Aging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Mitochondrial

Share to Mitochondria

Share to Mitochondrial Myopathies

Share to Models, Biological

Share to Oxidative Stress

Source

Identifiers

PMID: 16178023
DOI: 10.1002/ana.20624

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondria take center stage in aging and neurodegeneration.PMID 16178023Read ↗

Mitochondrial dysfunction in neurodegenerative disordersSemantic proximity Read ↗

Mitochondrial dysfunction in neurodegenerative disorders and ageing.Semantic proximity Read ↗

Mitochondrial Dysfunction: A Key Player in Brain Aging and DiseasesSemantic proximity Read ↗

Multiple Roles of Mitochondria in Aging ProcessesSemantic proximity Read ↗

Mitochondria as a Therapeutic Target for Aging and Neurodegenerative DiseasesSemantic proximity Read ↗

Insights into the Pathogenesis of Neurodegenerative Diseases: Focus on Mitochondrial Dysfunction and Oxidative StressSemantic proximity Read ↗

Novel therapeutic strategies targeting mitochondria as a gateway in neurodegenerationSemantic proximity Read ↗

Mitochondrial genetics: a paradigm for aging and degenerative diseases?Semantic proximity Read ↗

Mitochondrial DNA mutations associated with aging and degenerative diseases.Semantic proximity Read ↗

An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration.Semantic proximity Read ↗

Oxidative stress, mitochondrial DNA mutation, and apoptosis in aging.Semantic proximity Read ↗

Mitochondria and neurodegeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.