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Article

Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging.

Circulation - 2 Jun 2009

Dai Dao-Fu, Santana Luis F, Vermulst Marc, Tomazela Daniela M, Emond Mary J, MacCoss Michael J, Gollahon Katherine, Martin George M, Loeb Lawrence A, Ladiges Warren C, Rabinovitch Peter S

Abstract excerpt

BACKGROUND: Age is a major risk for cardiovascular diseases. Although mitochondrial reactive oxygen species have been proposed as one of the causes of aging, their role in cardiac aging remains unclear. We have previously shown that overexpression of catalase targeted to mitochondria (mCAT) prolongs murine median lifespan by 17% to 21%. METHODS AND RESULTS: We used echocardiography to study cardiac function in...

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Identifiers

PMID: 19451351
DOI: 10.1161/CIRCULATIONAHA.108.822403
PMCID: PMC2858759

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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