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Article

Parkin does not prevent accelerated cardiac aging in mitochondrial DNA mutator mice

16 Apr 2019

Abstract excerpt

The E3 ubiquitin ligase Parkin plays an important role in regulating clearance of dysfunctional or unwanted mitochondria in tissues, including the heart. However, whether Parkin also functions to prevent cardiac aging by maintaining a healthy population of mitochondria is still unclear. Here, we have examined the role of Parkin in the context of mtDNA damage and myocardial aging using a mouse model carrying a...

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PMID: 30990467
DOI: 10.1172/jci.insight.127713

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