Article
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging.
Science (New York, N.Y.) - 15 Jul 2005
Kujoth G C, Hiona A, Pugh T D, Someya S, Panzer K, Wohlgemuth S E, Hofer T, Seo A Y, Sullivan R, Jobling W A, Morrow J D, Van Remmen H, Sedivy J M, Yamasoba T, Tanokura M, Weindruch R, Leeuwenburgh C, Prolla T A
Abstract excerpt
Mutations in mitochondrial DNA (mtDNA) accumulate in tissues of mammalian species and have been hypothesized to contribute to aging. We show that mice expressing a proofreading-deficient version of the mitochondrial DNA polymerase g (POLG) accumulate mtDNA mutations and display features of accelerated aging. Accumulation of mtDNA mutations was not associated with increased markers of oxidative stress or a defect...
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