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Article

Several tetratricopeptide repeat (TPR) motifs of FANCG are required for assembly of the BRCA2/D1-D2-G-X3 complex, FANCD2 monoubiquitylation and phleomycin resistance.

Mutation research - 7 Jul 2010

Wilson James B, Blom Eric, Cunningham Ryan, Xiao Yuxuan, Kupfer Gary M, Jones Nigel J

Abstract excerpt

The Fanconi anaemia (FA) FANCG protein is an integral component of the FA nuclear core complex that is required for monoubiquitylation of FANCD2. FANCG is also part of another protein complex termed D1-D2-G-X3 that contains FANCD2 and the homologous recombination repair proteins BRCA2 (FANCD1) and XRCC3. Formation of the D1-D2-G-X3 complex is mediated by serine-7 phosphorylation of FANCG and occurs independently...

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Source

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Identifiers

PMID: 20450923
DOI: 10.1016/j.mrfmmm.2010.04.003
PMCID: PMC2903733

Genes

FANCG
FANCD2
BRCA2
TPR
XRCC3
FANCA
FANCF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Several tetratricopeptide repeat (TPR) motifs of FANCG are required for assembly of the BRCA2/D1-D2-G-X3 complex, FANCD2 monoubiquitylation and phleomycin resistance.PMID 20450923Read ↗

The Chinese hamster FANCG/XRCC9 mutant NM3 fails to express the monoubiquitinated form of the FANCD2 protein, is hypersensitive to a range of DNA damaging agents and exhibits a normal level of spontaneous sister chromatid exchange.Semantic proximity Read ↗

Targeted disruption of the murine Fanconi anemia gene, Fancg/Xrcc9.Semantic proximity Read ↗

Role of Fanconi anaemia proteins FANCG, FANCA and FANCD2 in the maintenance of chromosomal stabilitySemantic proximity Read ↗

Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia.Semantic proximity Read ↗

Fancl-mutant mice reveal central role of monoubiquitination in Fanconi anemia and a model for therapeutic gene editing.Semantic proximity Read ↗

RNF4-mediated polyubiquitination regulates the Fanconi anemia/BRCA pathway.Semantic proximity Read ↗

Coordinate nuclear targeting of the FANCD2 and FANCI proteins via a FANCD2 nuclear localization signal.Semantic proximity Read ↗

The Carboxyl Terminus of FANCE Recruits FANCD2 to the Fanconi Anemia (FA) E3 Ligase Complex to Promote the FA DNA Repair PathwaySemantic proximity Read ↗

Functional interaction between the Fanconi Anemia D2 protein and proliferating cell nuclear antigen (PCNA) via a conserved putative PCNA interaction motif.Semantic proximity Read ↗

Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin.Semantic proximity Read ↗

The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly.Semantic proximity Read ↗

A requirement of FancL and FancD2 monoubiquitination in DNA repair.Semantic proximity Read ↗

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