Article
Role of Fanconi anaemia proteins FANCG, FANCA and FANCD2 in the maintenance of chromosomal stability
2011-01-01
Abstract excerpt
Fanconi anaemia (FA) is a hereditary, heterogeneous disease that is characterized by chromosomal instability, hypersensitivity to DNA cross-linking agents and cancer. Fifteen FA genes are identified, mutations in any of which are known to cause FA: FANCA, B, C, DI, D2, E, F, G, I, J, L, M, N, 0, and P. Cell lines defective for any FA gene show cellular and cytogenetic hypersensitivity to DNA inter-strand cross-lin...
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Identifiers and source
- Literature Corpus work
- 281029bb-36b9-5315-a0f0-9151813b0d56
- DOI
- 10.17638/03062780