Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly.

The Journal of biological chemistry - 21 Apr 2006

Gurtan Allan M, Stuckert Patricia, D'Andrea Alan D

Abstract excerpt

Fanconi anemia (FA) is an autosomal recessive disorder characterized by aplastic anemia, cancer susceptibility, and cellular sensitivity to mitomycin C. Eight of the 11 cloned Fanconi anemia gene products (FANCA, -B, -C, -E, -F, -G, -L, and -M) form a multisubunit nuclear complex (FA core complex...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alkylating Agents
Share to Fanconi Anemia
Share to Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitomycin

Share to Proto-Oncogene Proteins c-cbl

Share to Retroviridae

Share to Tryptophan

Share to Ubiquitin

Source

Identifiers

PMID: 16474167
DOI: 10.1074/jbc.M511411200

Genes

FANCL
FANCD2
CBL
FANCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16474167-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly.PMID 16474167Read ↗

Structural analysis of human FANCL, the E3 ligase in the Fanconi anemia pathway.Semantic proximity Read ↗

The Genetic and Biochemical Basis of FANCD2 MonoubiquitinationSemantic proximity Read ↗

Fancl-mutant mice reveal central role of monoubiquitination in Fanconi anemia and a model for therapeutic gene editing.Semantic proximity Read ↗

Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.Semantic proximity Read ↗

Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair.Semantic proximity Read ↗

A requirement of FancL and FancD2 monoubiquitination in DNA repair.Semantic proximity Read ↗

Structural insight into FANCI-FANCD2 monoubiquitination.Semantic proximity Read ↗

A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network.Semantic proximity Read ↗

The Fanconi Anemia Pathway of Genomic MaintenanceSemantic proximity Read ↗

The Carboxyl Terminus of FANCE Recruits FANCD2 to the Fanconi Anemia (FA) E3 Ligase Complex to Promote the FA DNA Repair PathwaySemantic proximity Read ↗

Coordinate nuclear targeting of the FANCD2 and FANCI proteins via a FANCD2 nuclear localization signal.Semantic proximity Read ↗

Identification and characterization of mutations in FANCL gene: a second case of Fanconi anemia belonging to FA-L complementation group.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.