Article
The Chinese hamster FANCG/XRCC9 mutant NM3 fails to express the monoubiquitinated form of the FANCD2 protein, is hypersensitive to a range of DNA damaging agents and exhibits a normal level of spontaneous sister chromatid exchange.
Carcinogenesis - 1 Dec 2001
Wilson J B, Johnson M A, Stuckert A P, Trueman K L, May S, Bryant P E, Meyn R E, D'Andrea A D, Jones N J
Abstract excerpt
Fanconi anemia (FA) is a human autosomal disorder characterized by cancer susceptibility and cellular sensitivity to DNA crosslinking agents such as mitomycin C and diepoxybutane. Six FA genes have been cloned including a gene designated XRCC9 (for X-ray Repair Cross Complementing), isolated using a mitomycin C-hypersensitive Chinese hamster cell mutant termed UV40, and subsequently found to be identical to...
Topics
- Animals
- Bleomycin
- CHO Cells
- Cell Line
- Cricetinae
- DNA Damage
- DNA-Binding Proteins
- Epoxy Compounds
- Fanconi Anemia
- Fanconi Anemia Complementation Group D2 Protein