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Article

Functional interaction between the Fanconi Anemia D2 protein and proliferating cell nuclear antigen (PCNA) via a conserved putative PCNA interaction motif.

The Journal of biological chemistry - 16 Oct 2009

Howlett Niall G, Harney Julie A, Rego Meghan A, Kolling Frederick W, Glover Thomas W

Abstract excerpt

Fanconi Anemia (FA) is a rare recessive disease characterized by congenital abnormalities, bone marrow failure, and cancer susceptibility. The FA proteins and the familial breast cancer susceptibility gene products, BRCA1 and FANCD1/BRCA2, function cooperatively in the FA-BRCA pathway to repair damaged DNA and to prevent cellular transformation. Activation of this pathway occurs via the mono-ubiquitination of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 19704162
DOI: 10.1074/jbc.M109.016352
PMCID: PMC2781439

Genes

FANCD2
PCNA
BRCA2
PIP
BRCA1
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Functional interaction between the Fanconi Anemia D2 protein and proliferating cell nuclear antigen (PCNA) via a conserved putative PCNA interaction motif.PMID 19704162Read ↗

Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin.Semantic proximity Read ↗

Coordinate nuclear targeting of the FANCD2 and FANCI proteins via a FANCD2 nuclear localization signal.Semantic proximity Read ↗

Regulation of the Fanconi anemia pathway by a CUE ubiquitin-binding domain in the FANCD2 protein.Semantic proximity Read ↗

The Fanconi anemia proteins FANCD2 and FANCJ interact and regulate each other's chromatin localization.Semantic proximity Read ↗

Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.Semantic proximity Read ↗

Fanconi anemia and DNA repair.Semantic proximity Read ↗

Structure of the FANCI-FANCD2 Complex: Insights into the Fanconi Anemia DNA Repair PathwaySemantic proximity Read ↗

Direct interaction of FANCD2 with BRCA2 in DNA damage response pathwaysSemantic proximity Read ↗

Fanconi anaemia and cancer: an intricate relationship.Semantic proximity Read ↗

Overlooked FANCD2 variant encodes a promising, portent tumor suppressor, and alternative polyadenylation contributes to its expressionSemantic proximity Read ↗

Structural insight into FANCI-FANCD2 monoubiquitination.Semantic proximity Read ↗

The identification of FANCD2 DNA binding domains reveals nuclear localization sequences.Semantic proximity Read ↗

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