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Article

Coordinate nuclear targeting of the FANCD2 and FANCI proteins via a FANCD2 nuclear localization signal.

PloS one - 1 Jan 2013

Boisvert Rebecca A, Rego Meghan A, Azzinaro Paul A, Mauro Maurizio, Howlett Niall G

Abstract excerpt

Fanconi anemia (FA) is a rare recessive disease, characterized by congenital defects, bone marrow failure, and increased cancer susceptibility. FA is caused by biallelic mutation of any one of sixteen genes. The protein products of these genes function cooperatively in the FA-BRCA pathway to repair DNA interstrand crosslinks (ICLs). A central step in the activation of this pathway is the monoubiquitination of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24278431
DOI: 10.1371/journal.pone.0081387
PMCID: PMC3836817

Genes

FANCD2
FANCI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Coordinate nuclear targeting of the FANCD2 and FANCI proteins via a FANCD2 nuclear localization signal.PMID 24278431Read ↗

The identification of FANCD2 DNA binding domains reveals nuclear localization sequences.Semantic proximity Read ↗

The Fanconi anemia proteins FANCD2 and FANCJ interact and regulate each other's chromatin localization.Semantic proximity Read ↗

Fanconi anemia and DNA repair.Semantic proximity Read ↗

Structural insight into FANCI-FANCD2 monoubiquitination.Semantic proximity Read ↗

Functional interaction between the Fanconi Anemia D2 protein and proliferating cell nuclear antigen (PCNA) via a conserved putative PCNA interaction motif.Semantic proximity Read ↗

Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin.Semantic proximity Read ↗

The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly.Semantic proximity Read ↗

Regulation of the Fanconi anemia pathway by a CUE ubiquitin-binding domain in the FANCD2 protein.Semantic proximity Read ↗

Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia.Semantic proximity Read ↗

Dynamics of Fanconi anemia protein D2 in association with nuclear lipid droplet formationSemantic proximity Read ↗

The Genetic and Biochemical Basis of FANCD2 MonoubiquitinationSemantic proximity Read ↗

Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.Semantic proximity Read ↗

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