Article
Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia.
Blood - 21 Oct 2010
Pulliam-Leath Anna C, Ciccone Samantha L, Nalepa Grzegorz, Li Xiaxin, Si Yue, Miravalle Leticia, Smith Danielle, Yuan Jin, Li Jingling, Anur Praveen, Orazi Attilio, Vance Gail H, Yang Feng-Chun, Hanenberg Helmut, Bagby Grover C, Clapp D Wade
Abstract excerpt
Fanconi anemia (FA) is an inherited chromosomal instability syndrome characterized by bone marrow failure, myelodysplasia (MDS), and acute myeloid leukemia (AML). Eight FA proteins associate in a nuclear core complex to monoubiquitinate FANCD2/FANCI in response to DNA damage. Additional functions have been described for some of the core complex proteins; however, in vivo genetic proof has been lacking. Here we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.