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Article

A requirement of FancL and FancD2 monoubiquitination in DNA repair.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Mar 2007

Seki Sohsuke, Ohzeki Mioko, Uchida Akiko, Hirano Seiki, Matsushita Nobuko, Kitao Hiroyuki, Oda Tsukasa, Yamashita Takayuki, Kashihara Naoki, Tsubahara Akio, Takata Minoru, Ishiai Masamichi

Abstract excerpt

The rare hereditary disorder Fanconi anemia (FA) can be caused by mutations in components of the FA core complex (FancA/B/C/E/F/G/L/M), a key regulator FancD2, the breast cancer susceptibility protein BRCA2/FancD1, or the newly identified FancJ/BRIP1 helicase. By performing yeast two-hybrid (Y2H)...

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Source

Identifiers

PMID: 17352736
DOI: 10.1111/j.1365-2443.2007.01054.x

Genes

FANCL
BRCA2
BRIP1
FANCD2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17352736-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A requirement of FancL and FancD2 monoubiquitination in DNA repair.PMID 17352736Read ↗

The Genetic and Biochemical Basis of FANCD2 MonoubiquitinationSemantic proximity Read ↗

The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly.Semantic proximity Read ↗

Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin.Semantic proximity Read ↗

Fancl-mutant mice reveal central role of monoubiquitination in Fanconi anemia and a model for therapeutic gene editing.Semantic proximity Read ↗

Fanconi anemia and DNA repair.Semantic proximity Read ↗

Drosophila homologs of FANCD2 and FANCL function in DNA repair.Semantic proximity Read ↗

Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.Semantic proximity Read ↗

Fanconi anaemia and cancer: an intricate relationship.Semantic proximity Read ↗

Coordinate nuclear targeting of the FANCD2 and FANCI proteins via a FANCD2 nuclear localization signal.Semantic proximity Read ↗

The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia.Semantic proximity Read ↗

The Fanconi Anemia Pathway of Genomic MaintenanceSemantic proximity Read ↗

BRCA1-independent ubiquitination of FANCD2.Semantic proximity Read ↗

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