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Article

RNF4-mediated polyubiquitination regulates the Fanconi anemia/BRCA pathway.

The Journal of clinical investigation - 1 Apr 2015

Xie Jenny, Kim Hyungjin, Moreau Lisa A, Puhalla Shannon, Garber Judy, Al Abo Muthana, Takeda Shunichi, D'Andrea Alan D

Abstract excerpt

The Fanconi anemia/BRCA (FA/BRCA) pathway is a DNA repair pathway that is required for excision of DNA interstrand cross-links. The 17 known FA proteins, along with several FA-associated proteins (FAAPs), cooperate in this pathway to detect, unhook, and excise DNA cross-links and to subsequently repair the double-strand breaks generated in the process. In the current study, we identified a patient with FA with a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25751062
DOI: 10.1172/JCI79325
PMCID: PMC4396491

Genes

FANCA
RNF4
FAAP20

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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RNF4-mediated polyubiquitination regulates the Fanconi anemia/BRCA pathway.PMID 25751062Read ↗

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