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The Carboxyl Terminus of FANCE Recruits FANCD2 to the Fanconi Anemia (FA) E3 Ligase Complex to Promote the FA DNA Repair Pathway

23 Jan 2014

Abstract excerpt

Fanconi anemia (FA) is a genome instability syndrome characterized by bone marrow failure and cellular hypersensitivity to DNA cross-linking agents. In response to DNA damage, the FA pathway is activated through the cooperation of 16 FA proteins. A central player in the pathway is a multisubunit E3 ubiquitin ligase complex or the FA core complex, which monoubiquitinates its substrates FANCD2 and FANCI. FANCE, a...

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PMID: 24451376
DOI: 10.1074/jbc.m113.533976

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Carboxyl Terminus of FANCE Recruits FANCD2 to the Fanconi Anemia (FA) E3 Ligase Complex to Promote the FA DNA Repair PathwayPMID 24451376Read ↗

FANCC, FANCE, and FANCD2 form a ternary complex essential to the integrity of the Fanconi anemia DNA damage response pathway.Semantic proximity Read ↗

Insights into Fanconi Anaemia from the structure of human FANCE.Semantic proximity Read ↗

RNF4-mediated polyubiquitination regulates the Fanconi anemia/BRCA pathway.Semantic proximity Read ↗

Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair.Semantic proximity Read ↗

The Genetic and Biochemical Basis of FANCD2 MonoubiquitinationSemantic proximity Read ↗

The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly.Semantic proximity Read ↗

A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network.Semantic proximity Read ↗

Structural insight into FANCI-FANCD2 monoubiquitination.Semantic proximity Read ↗

Fancl-mutant mice reveal central role of monoubiquitination in Fanconi anemia and a model for therapeutic gene editing.Semantic proximity Read ↗

Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.Semantic proximity Read ↗

Coordinate nuclear targeting of the FANCD2 and FANCI proteins via a FANCD2 nuclear localization signal.Semantic proximity Read ↗

Structural analysis of human FANCL, the E3 ligase in the Fanconi anemia pathway.Semantic proximity Read ↗

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