Article
Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious diseases.
Clinical and experimental immunology - 1 May 2015
Skevaki C, Pararas M, Kostelidou K, Tsakris A, Routsias J G
Abstract excerpt
Toll-like receptors (TLRs) are the best-studied family of pattern-recognition receptors (PRRs), whose task is to rapidly recognize evolutionarily conserved structures on the invading microorganisms. Through binding to these patterns, TLRs trigger a number of proinflammatory and anti-microbial responses, playing a key role in the first line of defence against the pathogens also promoting adaptive immunity...
Topics
- Genetic Predisposition to Disease
- Humans
- Immunity, Innate
- Infections
- Polymorphism, Single Nucleotide
- Toll-Like Receptors