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Article

Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease.

PloS one - 19 Dec 2007

Ma Xin, Liu Yuhua, Gowen Brian B, Graviss Edward A, Clark Andrew G, Musser James M

Abstract excerpt

Tuberculosis (TB) is the leading cause of death worldwide due to an infectious agent. Data have accumulated over decades suggesting that variability in human susceptibility to TB disease has a genetic component. Toll-like receptors (TLRs) play a critical role in initiating the innate immune response to many pathogens in mouse models, but little is known about their role in human infections. Human TLRs have been...

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Identifiers

PMID: 18091991
DOI: 10.1371/journal.pone.0001318
PMCID: PMC2117342

Genes

TLR1
TLR6
TLR10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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