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Article

Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family.

Human mutation - 1 Jun 2011

Ben-Ali Meriem, Corre Beatrice, Manry Jérémy, Barreiro Luis B, Quach Hélène, Boniotto Michele, Pellegrini Sandra, Quintana-Murci Lluís

Abstract excerpt

Toll-like receptors (TLRs) are considered an essential component of the innate immune system, initiating inflammatory responses following infection of the host. Humans have 10 functional TLRs, differing in their subcellular distributions and the microbial agonists they sense. The phylogenetically conserved TLR1-2-6 family is unique in that TLR1 and TLR6 form heterodimers with TLR2 to mediate signalling in...

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Source

Identifiers

PMID: 21618349
DOI: 10.1002/humu.21486

Genes

TLR1
TLR2
TLR6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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