Article
Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment.
Annals of the rheumatic diseases - 1 Jun 2010
Tan Rachael J L, Gibbons Laura J, Potter Catherine, Hyrich Kimme L, Morgan Ann W, Wilson Anthony G, Isaacs John D, Barton Anne
Abstract excerpt
BACKGROUND: Anti-tumour necrosis factor (anti-TNF) therapy has proved to be highly successful in treating rheumatoid arthritis (RA), although 30-40% of patients have little or no response. The authors hypothesise that this may be genetically determined. In other complex diseases, susceptibility genes have been shown to influence treatment response. The aim of the current study was to investigate the association...
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