Genetic variants within immune-modulating genes influence the risk of developing rheumatoid arthritis and anti-TNF drug response: a two-stage case-control study.

doi:10.1097/FPC.0000000000000155

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Genetic variants within immune-modulating genes influence the risk of developing rheumatoid arthritis and anti-TNF drug response: a two-stage case-control study.

Pharmacogenetics and genomics - 1 Sept 2015

Canet Luz M, Cáliz Rafael, Lupiañez Carmen B, Canhão Helena, Martinez Manuel, Escudero Alejandro, Filipescu Ileana, Segura-Catena Juana, Soto-Pino María J, Ferrer Miguel A, García Antonio, Romani Lurdes, Pérez-Pampin Eva, González-Utrilla Alfonso, López Nevot Miguel Ángel, Collantes Eduardo, Fonseca João E, Sainz Juan

Abstract excerpt

BACKGROUND: Rheumatoid arthritis (RA) is a chronic autoimmune disease that arises as a result of the interaction between genetic and environmental factors. A growing body of research suggests that genetic variants within immune-related genes can influence the risk of developing the disease and affect drug response. MATERIALS AND METHODS: To test this hypothesis, we carried out a comprehensive two-stage...

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PMID: 26111149
DOI: 10.1097/FPC.0000000000000155

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IFNG

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