Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment.

doi:10.1136/annrheumdis-2013-203276

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Article

Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment.

Annals of the rheumatic diseases - 1 Jun 2014

Mathews Rebeccah J, Robinson James I, Battellino Michele, Wong Chi, Taylor John C, Eyre Steve, Churchman Sarah M, Wilson Anthony G, Isaacs John D, Hyrich Kimme, Barton Anne, Plant Darren, Savic Sinisa, Cook Graham P, Sarzi-Puttini Piercarlo, Emery Paul, Barrett Jennifer H, Morgan Ann W, McDermott Michael F

Abstract excerpt

BACKGROUND: The NLRP3-inflammasome, implicated in the pathogenesis of several inflammatory disorders, has been analysed in rheumatoid arthritis (RA). METHODS: Relative gene expression of NLRP3-inflammasome components was characterised in PBMCs of 29 patients receiving infliximab. A total of 1278 Caucasian patients with RA from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS)...

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Identifiers

PMID: 23687262
DOI: 10.1136/annrheumdis-2013-203276

Genes

NLRP3
TNF
CARD8
MEFV
CASP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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