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Article

Anti-TNF treatment response in rheumatoid arthritis patients is associated with genetic variation in the NLRP3-inflammasome.

PloS one - 1 Jan 2014

Sode Jacob, Vogel Ulla, Bank Steffen, Andersen Paal Skytt, Thomsen Marianne Kragh, Hetland Merete Lund, Locht Henning, Heegaard Niels H H, Andersen Vibeke

Abstract excerpt

OBJECTIVE: Many patients with rheumatoid arthritis (RA) benefit from tumor necrosis factor-α blocking treatment (anti-TNF), but about one third do not respond. The objective of this study was to replicate and extend previously found associations between anti-TNF treatment response and genetic variation in the TNF-, NF-κB- and pattern recognition receptor signalling pathways. METHODS: Forty-one single nucleotide...

Read the complete abstract on PubMed

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Share to Antirheumatic Agents
Share to Arthritis, Rheumatoid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to NLR Family, Pyrin Domain-Containing 3 Protein

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Source

Open in PubMed Open full text

Identifiers

PMID: 24967817
DOI: 10.1371/journal.pone.0100361
PMCID: PMC4072633

Genes

TNF
NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Anti-TNF treatment response in rheumatoid arthritis patients is associated with genetic variation in the NLRP3-inflammasome.PMID 24967817Read ↗

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