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Article

Variation at FCGR2A and functionally related genes is associated with the response to anti-TNF therapy in rheumatoid arthritis.

PloS one - 1 Jan 2015

Avila-Pedretti Gabriela, Tornero Jesús, Fernández-Nebro Antonio, Blanco Francisco, González-Alvaro Isidoro, Cañete Juan D, Maymó Joan, Alperiz Mercedes, Fernández-Gutiérrez Benjamín, Olivé Alex, Corominas Héctor, Erra Alba, Aterido Adrià, López Lasanta María, Tortosa Raül, Julià Antonio, Marsal Sara

Abstract excerpt

OBJECTIVE: Anti-TNF therapies have been highly efficacious in the management of rheumatoid arthritis (RA), but 25-30% of patients do not show a significant clinical response. There is increasing evidence that genetic variation at the Fc receptor FCGR2A is associated with the response to anti-TNF...

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Share to Antirheumatic Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 25848939
DOI: 10.1371/journal.pone.0122088
PMCID: PMC4388501

Genes

TNF
RGS12
DHX32

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25848939-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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