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Article

Investigation of single nucleotide polymorphisms and biological pathways associated with response to TNFα inhibitors in patients with rheumatoid arthritis.

Pharmacogenetics and genomics - 1 Aug 2012

Krintel Sophine B, Palermo Giuseppe, Johansen Julia S, Germer Søren, Essioux Laurent, Benayed Ryma, Badi Laura, Ostergaard Mikkel, Hetland Merete L

Abstract excerpt

OBJECTIVE: Recently, two genome-wide association studies identified single nucleotide polymorphisms (SNPs) significantly associated with the treatment response to tumor necrosis factor α (TNFα) inhibitors in patients with rheumatoid arthritis (RA). We aimed to replicate these results and identify SNPs and the possible biological pathways associated with the treatment response to TNFα inhibitors. METHODS:...

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Share to Adalimumab
Share to Antibodies, Monoclonal, Humanized

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arthritis, Rheumatoid

Share to Biomarkers, Pharmacological

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Share to Immunoglobulin G

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Share to Receptors, Tumor Necrosis Factor

Source

Identifiers

PMID: 22569225
DOI: 10.1097/FPC.0b013e3283544043

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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