Article
Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritis.
Annals of the rheumatic diseases - 1 Aug 2013
Umiċeviċ Mirkov Maša, Cui Jing, Vermeulen Sita H, Stahl Eli A, Toonen Erik J M, Makkinje Remco R, Lee Annette T, Huizinga Tom W J, Allaart Renee, Barton Anne, Mariette Xavier, Miceli Corinne Richard, Criswell Lindsey A, Tak Paul P, de Vries Niek, Saevarsdottir Saedis, Padyukov Leonid, Bridges S Louis, van Schaardenburg Dirk-Jan, Jansen Tim L, Dutmer Ellen A J, van de Laar Mart A F J, Barrera Pilar, Radstake Timothy R D J, van Riel Piet L C M, Scheffer Hans, Franke Barbara, Brunner Han G, Plenge Robert M, Gregersen Peter K, Guchelaar Henk-Jan, Coenen Marieke J H
Abstract excerpt
BACKGROUND: Treatment strategies blocking tumour necrosis factor (anti-TNF) have proven very successful in patients with rheumatoid arthritis (RA). However, a significant subset of patients does not respond for unknown reasons. Currently, there are no means of identifying these patients before treatment. This study was aimed at identifying genetic factors predicting anti-TNF treatment outcome in patients with RA...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.