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Article

Genetic Variations in Pattern Recognition Receptor Loci Are Associated with Anti-TNF Response in Patients with Rheumatoid Arthritis.

PloS one - 1 Jan 2015

Sode Jacob, Vogel Ulla, Bank Steffen, Andersen Paal Skytt, Hetland Merete Lund, Locht Henning, Heegaard Niels H H, Andersen Vibeke

Abstract excerpt

OBJECTIVES: To determine whether genetic variation within genes related to the Toll-like receptor, inflammasome and interferon-γ pathways contributes to the differences in treatment response to tumour necrosis factor inhibitors (anti-TNF) in patients with rheumatoid arthritis (RA). METHODS: In a retrospective case-case study, we assessed 23 functional single nucleotide polymorphisms (SNPs) in 15 genes. We...

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Identifiers

PMID: 26440629
DOI: 10.1371/journal.pone.0139781
PMCID: PMC4595012

Genes

TNF
TLR5
NLRP3
TLR1
TLR10

Provenance

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