Article
Genome-wide association study of genetic predictors of anti-tumor necrosis factor treatment efficacy in rheumatoid arthritis identifies associations with polymorphisms at seven loci.
Arthritis and rheumatism - 1 Mar 2011
Plant Darren, Bowes John, Potter Catherine, Hyrich Kimme L, Morgan Ann W, Wilson Anthony G, Isaacs John D, Barton Anne
Abstract excerpt
OBJECTIVE: Anti-tumor necrosis factor (anti-TNF) agents are successful therapies in rheumatoid arthritis (RA); however, inadequate response occurs in 30-40% of patients treated. Knowledge of the genetic factors that influence response may facilitate personalized therapy. The purpose of this study was to identify genetic predictors of response to anti-TNF therapy in RA and to validate our findings in independent...
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