Article
Dynamic phosphorylation of the kinesin Costal-2 in vivo reveals requirement of fused kinase activity for all levels of hedgehog signalling.
Developmental biology - 1 Aug 2010
Raisin S, Ruel L, Ranieri N, Staccini-Lavenant L, Thérond P P
Abstract excerpt
Hedgehog (Hh) proteins are secreted molecules that play an essential role in development and tumorigenesis. In Drosophila cultured cells, phosphorylation of the kinesin-like Costal2 (Cos2) protein at Ser572 is triggered by the kinase fused (Fu) upon Hh pathway activation. Here, we validate the first phospho-antibody for one of the Hh pathway components, Cos2, as a universal in situ readout of Hh signal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.